| Local Channels (Sikeston Satellite TV) | | 3 | 3 | WSIL | Some Programs On ABC: World News Now, True Beauty, Scrubs, WNBA, Belmont Stakes, The Goode Family, Supernanny, Primetime, All My Children, NBA on ABC, Saturday Night College Football, According to Jim, and The View. | Local | Local |
| 6 | 6 | WPSD | Some Programs On NBC: Notre Dame home Football games, Law & Order: Special Victims Unit, Jane and the Dragon, Main article: NBC Sports, Early Today, The Olympics through 2012, Last Call with Carson Daly, The NHL, Wimbledon Tennis, 30 Rock, Merlin, Miss USA, and Kath & Kim. | Local | Local |
| 8 | 8 | WSIU | Some Programs On PBS: Are You Being Served?, Between the Lions, The Woodwright's Shop, Carrier, The NewsHour with Jim Lehrer, Clifford the Big Red Dog, P.O.V., The Berenstain Bears, Washington Week, DragonflyTV, Dragon Tales, Religion & Ethics Newsweekly, and George Shrinks. | Local | Local |
| 9 | - | WQWQ | Some Programs On CW: 90210, America's Next Top Model, Privileged, Gossip Girl, Jericho, Smallville, The Game, Reaper, The Drew Carey Show, Everybody Hates Chris, Stylista, One Tree Hill, and Supernatural. | Local | - |
| 12 | 12 | KFVS | Some Programs On CBS: Million Dollar Password, CSI: Crime Scene Investigation, The Amazing Race, Up to the Minute, Eleventh Hour, Big Brother, How I Met Your Mother, CSI: NY, Academy of Country Music Awards, Strawberry Shortcake, Cold Case, CSI: Miami, and PGA Tour Golf. | Local | Local |
| - | 15 | WKPC | Some Programs On PBS: Are You Being Served?, Between the Lions, The Woodwright's Shop, Carrier, The NewsHour with Jim Lehrer, Clifford the Big Red Dog, P.O.V., The Berenstain Bears, Washington Week, DragonflyTV, Dragon Tales, Religion & Ethics Newsweekly, and George Shrinks. | - | Local |
| 23 | 23 | KBSI | Some Programs On FOX: Hell's Kitchen, Terminator: The Sarah Connor Chronicles, Til Death, House, King of the Hill, American Idol, COPS, MADtv, Kitchen Nightmares, Lie to Me, Teen Choice Awards, Don't Forget the Lyrics!, and Fringe. | Local | Local |
| - | 27 | WTCT | WTCT (TCT) | - | Local |
| 29 | - | WKPD | Some Programs On PBS: Are You Being Served?, Between the Lions, The Woodwright's Shop, Carrier, The NewsHour with Jim Lehrer, Clifford the Big Red Dog, P.O.V., The Berenstain Bears, Washington Week, DragonflyTV, Dragon Tales, Religion & Ethics Newsweekly, and George Shrinks. | Local | - |
| 49 | 49 | WDKA | WDKA (MNT) | Local | Local |
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